The 9 Scariest Plagues In Gaming, Ranked

The 9 Scariest Plagues In Gaming, Ranked

Diseases are one way that video games can drive their narrative. Whether it’s motivating your character to advance the plot or explaining a huge change in the world, they’re a handy tool in any developer’s belt.


Best Disease and Outbreak Games, Ranked In some games, disease is just one more thing in a long list of status effects your character can heal. Others, however, like to heighten the horror and create plagues that will give you nightmares. They’re fictional, sure, but the way the games portray them is real enough that you want to avoid them at all costs.


9 BLAME: Trauma Center

Trauma Center: Under the Knife might be famous for using, at the time, the newly released Nintendo DS stylus in its entirety, but instead it’s famous for featuring a host of neighboring diseases that are straight out of your childhood nightmares. These diseases, collectively referred to as GUILT, are part parasites, part toxins, and part devious terrorist plots to destroy all of humanity.

Fortunately for the world, you are a doctor with magical powers derived from the ancient Greek god of medicine and an unlimited number of retries to hit the touch controls. Its manifestations are terrifying, but with a little divine help, doomsday GUILT is but a footnote to the continued rise of humanity.

8 Radical-6: Virtue’s Ultimate Reward

The world-ending bug of the Zero Escape series seems innocuous enough compared to most viruses. There is no bleeding or cough. Instead, the virus slows brain function, causing you to perceive time slower than it actually is.

While this may not seem like a big deal, the slowdown quickly overwhelms your senses and makes living unbearable. This means that most people who get Radical-6 do not die directly from the virus. Instead, they take their own lives. It is dark.

7 The Gray Death: Deus Ex

You might think that the cybernetic enhancements in Deus Ex are a fun way to get good at something without having to practice, and for the most part, you’d be right. But while you can use them to outsmart Corvo Attano and outrun Usain Bolt, you’re also inviting the Gray Death into your body.

Originally created in a lab as population control, the gray death infects people with mechanical augmentations, with limited vaccinations only given to people who can afford the exorbitant price for one. Sometimes the price is a lot of money, but sometimes you have to give your allegiance to a worldwide secret society to keep yourself safe. Perhaps the real plague here is capitalism.

6 Cordyceps Fungus: The Last of Us

Everyone has their own zombie survival plan these days, but The Last of Us’ Cordyceps fungus throws them all out the window. Sure, you know how to remove the head or destroy the brain, but now you have to avoid the barely visible fungal spores and sneak past the mushroom-faced clickers. Hiding in your local mall doesn’t seem so good anymore after discovering that zombies are very fast and can sense movement.


The Most Dangerous Kinds Of Video Game Zombies, Ranked The scariest thing about Cordyceps, though, is that it’s a real thing. A species of Cordyceps is known to infect the brains of certain insects, and while it doesn’t infect humans, that doesn’t improve the picture.

5 Scarlet Rot: Elden Ring

Sure, you can technically walk through a Scarlet Rot lake in the Elden Ring without too many negative effects, but what the Scarlet Rot did to an entire corner of the Lands Between is horrible. Not only does it devastate the land of Caelid, but it seems to corrupt everything it touches, causing some victims to fall into a mindless rage. Even demigods are not immune.

You can live with the rot through magical means, like Malenia and Millicent, but getting there can’t be pleasant, especially since it seems to liquefy the limbs first, before going to the core.

4 Kharaa: Subnautica

Most of the time you’re exploring an alien world covered in water, you’re not too worried about getting sick. He’s probably focused on more pressing matters, like not getting eaten by the huge leviathan-class sea creatures that lurk in the depths.

But sickness is exactly what you’ll find once you dive into the waters of Subnautica. Kharaa is an ancient organism, predating humanity, that apparently killed over 143 billion members of the Precursor race and seems to take comfort in any organism it touches. Fortunately, there is a cure, but the body count alone should give you pause on your next trip to the beach.

3 The Bite: A Plague Tale

The Bite is what the folks at A Plague Tale call the Black Death, which, if you need a reminder, was very, very bad news. Not content with just showing the devastation of a disease that killed more than a third of Europe in four years, Asobo Studios reimagined the plague as something even more sinister, spread by hordes of vicious rats driven by a dark power.


Games to play if you like a plague tale: InnocenceThe Bite might not pack as much punch as some of the made-up diseases on this list, but it doesn’t have to. An entire continent is still coping with its collective plague trauma. Sometimes just mentioning it is enough.

two Genophagus: mass effect

Probably one of the cruelest tricks in the Council’s war arsenal, Mass Effect’s Genophage made it almost impossible for the Krogan race to reproduce. Sure, the Krogan fought endlessly, but Genophage essentially sentenced an entire species to death without actually killing them. The scariest thing about Genophage is not what it does to a single person, but rather that it throws an entire species into an existential crisis.

one Just All This: Resident Evil

Many diseases in games turn people into zombies, but very few are as utterly evil as the series of viruses that the Umbrella Corporation implements in Resident Evil from day one. Sure, they’ll make your zombies run-of-the-mill, but they’ll also turn you into a hulking, multi-limbed monstrosity or give you a massive blade for an arm, which would be great if they didn’t. make it impossible to pick up a glass of water. The many viruses in the Resident Evil series have an X factor (or perhaps a T factor) that makes their existence truly alarming.

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